Synthesis of a macrocycle based on Linked Amino Acid Mimetics (LAAM)

We report the synthesis of a macrocycle utilizing a novel framework of standard amino acids in combination with subunits that we have named as Linked Amino Acid Mimetics (LAAMs). Macrocycles based on the LAAM concept provide both a peptide targeting region and two independently variable functional regions. In the prototype structure, the commonly known Arg-Gly-Asp (RGD) sequence was used for the targeting region. The functional regions contain a phenyl group, and the linkage was formed via a Ring-Closing Metathesis (RCM) reaction.     

Voltammetric determination of tumor necrosis factor-α based on the use of an aptamer and magnetic nanoparticles loaded with gold nanoparticles

Microchimica Acta - The authors are presenting an electrochemical aptasensor for tumor necrosis factor-alpha (TNF-α) detection that is aided by the use of magnetic nanoparticles (NPs) and two...     

PEO/PVDF-based gel polymer electrolyte by incorporating nano-TiO2 for electrochromic glass

Journal of Sol-Gel Science and Technology - To develop high performance mixed matrix gel polymer electrolyte, the synergistic effect of blending PVDF (PEO/PVDF weigh ratio of 85:15) and adding...     

Experimental and LES investigation of premixed methane/air flame propagating in a tube with a thin obstacle

In this paper, an experimental and numerical investigation of premixed methane/air flame dynamics in a closed combustion vessel with a thin obstacle is described. In the experiment, high-speed video photography and a pressure transducer are used to study the flame shape changes and pressure dynamics. In the numerical simulation, four sub-grid scale viscosity models and three sub-grid scale combustion models are evaluated for their individual prediction compared with the experimental data. High-speed photographs show that the flame propagation process can be divided into five stages: spherical flame, finger-shaped flame, jet flame, mushroom-shaped flame and bidirectional propagation flame. Compared with the other sub-grid scale viscosity models and sub-grid scale combustion models, the dynamic Smagorinsky–Lilly model and the power-law flame wrinkling model are better able to predict the flame behaviour, respectively. Thus, coupling the dynamic Smagorinsky–Lilly model and the power-law flame wrinkling model, the numerical results demonstrate that flame shape change is a purely hydrodynamic phenomenon, and the mushroom-shaped flame and bidirectional propagation flame are the result of flame–vortex interaction. In addition, the transition from “corrugated flamelets” to “thin reaction zones” is observed in the simulation.     

基于公式真度的公式集约简

基于经典命题逻辑的真度理论,讨论了经典命题逻辑系统当中公式集的约简问题。提出了真度约简及α-真度约简的概念,为公式集的约简提供了一种可行的操作方法。